Screening for ALK in non-small cell lung carcinomas: 5A4 and D5F3 antibodies perform equally well, but combined use with FISH is recommended.

@article{Savic2015ScreeningFA,
  title={Screening for ALK in non-small cell lung carcinomas: 5A4 and D5F3 antibodies perform equally well, but combined use with FISH is recommended.},
  author={Spasenija Savic and Joachim Diebold and A K Zimmermann and Wolfram Jochum and Betty Baschiera and Susanne Grieshaber and Luigi Tornillo and Bettina Bisig and Keith M. Kerr and Lukas Bubendorf},
  journal={Lung cancer},
  year={2015},
  volume={89 2},
  pages={104-9}
}
OBJECTIVES Immunohistochemistry (IHC) has become a promising method for pre-screening ALK-rearrangements in non-small cell lung carcinomas (NSCLC). Various ALK antibodies, detection systems and automated immunostainers are available. We therefore aimed to compare the performance of the monoclonal 5A4 (Novocastra, Leica) and D5F3 (Cell Signaling, Ventana… CONTINUE READING