Corpus ID: 115132178

Screening flavonoids and their synthetic analogs to target liver cancer stem-like cells

  title={Screening flavonoids and their synthetic analogs to target liver cancer stem-like cells},
  author={T. Ma and Anfang Fan and Cai Lv and J. Cao and Kai-qun Ren},
Objective: Hepatocellular carcinoma (HCC) is one of the most malignant tumors having the highest death rate in the world. In this research, we aimed to screen effective compounds that targeted liver cancer stem-like cells (LCSLCs) from 9 flavonoids and synthetic analogues. Methods: Magnetic activated cell sorting and stem cell conditioned suspension culture were used to separate LCSLCs from Huh7 hepatoma cell lines. MTT assay and tumor sphere formation ability were used to detect inhibitory… Expand
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