Screening approach for chiral separation of pharmaceuticals part II. Reversed-phase liquid chromatography.

@article{Perrin2002ScreeningAF,
  title={Screening approach for chiral separation of pharmaceuticals part II. Reversed-phase liquid chromatography.},
  author={Catherine Perrin and Nele Matthijs and Debby Mangelings and Christine Granier-Loyaux and Mohamed Maftouh and Desire L. Massart and Yvan Vander Heyden},
  journal={Journal of chromatography. A},
  year={2002},
  volume={966 1-2},
  pages={119-34}
}
A screening strategy for the rapid separation of drug enantiomers by reversed-phase liquid chromatography was developed using three cellulose/amylose stationary phases. The key point to achieve enantioselectivity is the control of the compound ionisation. Only two mobile phases, i.e. an acidic phosphate buffer (pH 2.0) containing a chaotropic salt (KPF6) and a borate buffer (pH 9.0) mixed with acetonitrile, are used in the proposed strategy. This strategy was successfully applied to a set of 37… CONTINUE READING

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