Screening and structural analysis of flavones inhibiting tankyrases.

Abstract

Flavonoids are known for their beneficial effects on human health, and therefore the therapeutic potential of these compounds have been extensively studied. Flavone has been previously identified as a tankyrase inhibitor, and to further elucidate whether tankyrases would be inhibited by other flavonoids, we performed a systematic screening of tankyrase 2… (More)
DOI: 10.1021/jm3018783

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