Screening and prevention of hereditary gynecologic cancers.

  title={Screening and prevention of hereditary gynecologic cancers.},
  author={Siobhan M. Kehoe and Noah D. Kauff},
  journal={Seminars in oncology},
  volume={34 5},
Endometrial and ovarian cancer are the fourth and fifth most common malignancies in women, with approximately 40,000 new endometrial and 25,000 new ovarian cancers expected to be diagnosed in the Unites States this year. While the majority of these cancers will occur in the absence of a family history, approximately 5% of endometrial cancers and 10% of ovarian cancers will be the result of inherited defects in high-penetrance cancer susceptibility genes. With the identification and subsequent… CONTINUE READING