Screening and identification of small molecule compounds perturbing mitosis using time-dependent cellular response profiles.


Cellular processes such as cell cycle progression, mitosis, apoptosis, and cell migration are characterized by well-defined events that are modulated as a function of time. Measuring these events in the context of time and its perturbation by small molecule compounds and RNAi can provide mechanistic information about cellular pathways being affected. We… (More)
DOI: 10.1021/ac1007877


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