Screening and identification of novel B cell epitopes in human heparanase and their anti-invasion property for hepatocellular carcinoma

@article{Yang2008ScreeningAI,
  title={Screening and identification of novel B cell epitopes in human heparanase and their anti-invasion property for hepatocellular carcinoma},
  author={Jian-min Yang and Hui-ju Wang and Ling Du and Xiao Han and Zai‐yuan Ye and Yong-qi Fang and Hou‐quan Tao and Zhong-sheng Zhao and Yong-Lie Zhou},
  journal={Cancer Immunology, Immunotherapy},
  year={2008},
  volume={58},
  pages={1387-1396}
}
BackgroundThe aim of this study was to screen and identify novel B cell epitopes within the human heparanase protein and to investigate the impact of self-developed anti-heparanase polypeptide antibodies on growth and invasion of HCCLM6 human hepatocellular carcinoma cells in vitro.MethodsThe flexible regions of secondary structure and the B cell epitopes of the human heparanase amino acid sequence were predicted by DNAStar and Bcepred software.The multiple antigenic peptides (MAP) of the… 
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