Screening and Replication using the Same Data Set: Testing Strategies for Family-Based Studies in which All Probands Are Affected

@article{Murphy2008ScreeningAR,
  title={Screening and Replication using the Same Data Set: Testing Strategies for Family-Based Studies in which All Probands Are Affected},
  author={Amy E. Murphy and Scott T. Weiss and Christoph Lange},
  journal={PLoS Genetics},
  year={2008},
  volume={4},
  pages={1299 - 1320}
}
For genome-wide association studies in family-based designs, we propose a powerful two-stage testing strategy that can be applied in situations in which parent-offspring trio data are available and all offspring are affected with the trait or disease under study. In the first step of the testing strategy, we construct estimators of genetic effect size in the completely ascertained sample of affected offspring and their parents that are statistically independent of the family-based association… CONTINUE READING
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