Corpus ID: 89529299

Screening and Mutation of Strain to Resolve of Ethyl 3-Phenylglycidate

  title={Screening and Mutation of Strain to Resolve of Ethyl 3-Phenylglycidate},
  author={Xue Dong-sheng},
  journal={The Chinese Pharmaceutical Journal},
  • Xue Dong-sheng
  • Published 2010
  • Chemistry
  • The Chinese Pharmaceutical Journal
OBECTIVE To obtain,selecte and mutate (2R,3S)-ethyl 3-phenylglycidate which was able to resolve efficiently ethyl 3-phenylglycidate.METHODS The strain was identified by physiological and biochemical methods.The strain was mutated by ultraviolet and NTG.RESULTS Pseudomonas pseudoalcaligene showed excellent property.The yield of (2R,3S)-ethyl 3-phenylglycidate was increased to 82%.CONCLUSION It was a new method to produce intermediate of ABT-770.