Screening analysis for medicinal drugs and drugs of abuse in whole blood using ultra-performance liquid chromatography time-of-flight mass spectrometry (UPLC-TOF-MS)--toxicological findings in cases of alleged sexual assault.

@article{Birkler2012ScreeningAF,
  title={Screening analysis for medicinal drugs and drugs of abuse in whole blood using ultra-performance liquid chromatography time-of-flight mass spectrometry (UPLC-TOF-MS)--toxicological findings in cases of alleged sexual assault.},
  author={Rune Isak Dupont Birkler and Rasmus Telving and O. I. Ingemann-Hansen and Annie Vesterby Charles and Mogens Johannsen and Mette Findal Andreasen},
  journal={Forensic science international},
  year={2012},
  volume={222 1-3},
  pages={
          154-61
        }
}
An ultra-performance liquid chromatography time-of-flight mass spectrometry (UPLC-TOF-MS) method for simultaneous screening of 46 medicinal drugs and drugs of abuse in whole blood was developed and validated. The method includes most of the commonly used and abused drugs such as amphetamines, cocaine, benzodiazepines, and opioids. Chromatographic separation of the targeted drugs was achieved using a Waters ACQUITY UPLC coupled to a Waters Micromass LCT Premier XE time-of-flight mass… CONTINUE READING
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