Screening a natural product-based combinatorial library using FTICR mass spectrometry.

  title={Screening a natural product-based combinatorial library using FTICR mass spectrometry.},
  author={S. Poulsen and R. Davis and Timothy G. Keys},
  journal={Bioorganic & medicinal chemistry},
  volume={14 2},
  • S. Poulsen, R. Davis, Timothy G. Keys
  • Published 2006
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • This manuscript reports the use of Fourier transform ion cyclotron resonance mass spectrometry to screen a combinatorially generated natural product-based library for binding affinity to bovine carbonic anhydrase II (bCAII). The fungal natural product 3-chloro-4-hydroxyphenylacetamide was the library template, with 11 secondary amide analogues of this template constituting the combinatorial library. 2-(3-Chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide (compound 11) of this library was… CONTINUE READING
    27 Citations

    Tables and Topics from this paper

    Direct screening of a dynamic combinatorial library using mass spectrometry
    • S. Poulsen
    • Chemistry, Medicine
    • Journal of the American Society for Mass Spectrometry
    • 2006
    • 61
    • PDF
    Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.
    • 79
    • PDF
    High impact technologies for natural products screening.
    • F. Koehn
    • Computer Science, Medicine
    • Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
    • 2008
    • 95
    Natural product coumarins that inhibit human carbonic anhydrases.
    • 72
    • PDF
    Advances in MS Based Strategies for Probing Ligand-Target Interactions: Focus on Soft Ionization Mass Spectrometric Techniques
    • 3
    • PDF
    Metabolomics for bioactivity assessment of natural products
    • 112
    • PDF


    The role of natural product chemistry in drug discovery.
    • 1,077
    • PDF
    Anticancer and antiviral sulfonamides.
    • 477