Screening a natural product-based combinatorial library using FTICR mass spectrometry.

@article{Poulsen2006ScreeningAN,
  title={Screening a natural product-based combinatorial library using FTICR mass spectrometry.},
  author={S. Poulsen and R. Davis and Timothy G. Keys},
  journal={Bioorganic & medicinal chemistry},
  year={2006},
  volume={14 2},
  pages={
          510-5
        }
}
  • S. Poulsen, R. Davis, Timothy G. Keys
  • Published 2006
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • This manuscript reports the use of Fourier transform ion cyclotron resonance mass spectrometry to screen a combinatorially generated natural product-based library for binding affinity to bovine carbonic anhydrase II (bCAII). The fungal natural product 3-chloro-4-hydroxyphenylacetamide was the library template, with 11 secondary amide analogues of this template constituting the combinatorial library. 2-(3-Chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide (compound 11) of this library was… CONTINUE READING
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