Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer.

@article{Janssen2004ScreeningAC,
  title={Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer.},
  author={Samuel Janssen and Carsten M Jakobsen and David M. Rosen and Rebecca M Ricklis and Ulrich Reineke and S Brogger Christensen and Hans G Lilja and Samuel R Denmeade},
  journal={Molecular cancer therapeutics},
  year={2004},
  volume={3 11},
  pages={1439-50}
}
OBJECTIVE Prostate cancer cells secrete the unique protease human glandular kallikrein 2 (hK2) that represents a target for proteolytic activation of cytotoxic prodrugs. The objective of this study was to identify hK2-selective peptide substrates that could be coupled to a cytotoxic analogue of thapsigargin, a potent inhibitor of the sarcoplasmic/endoplasmic reticulum calcium ATPase pump that induces cell proliferation-independent apoptosis through dysregulation of intracellular calcium levels… CONTINUE READING
10 Citations
44 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

xenograft models

  • A Christensson, CB Laurell, H Lilja
  • Prostate
  • 2001

Similar Papers

Loading similar papers…