Screening, confirmation and quantification of diuretics in urine for doping control analysis by high-performance liquid chromatography-atmospheric pressure ionisation tandem mass spectrometry.

@article{Thieme2001ScreeningCA,
  title={Screening, confirmation and quantification of diuretics in urine for doping control analysis by high-performance liquid chromatography-atmospheric pressure ionisation tandem mass spectrometry.},
  author={Detlef Thieme and Joachim Grosse and Rainer Lang and R. K. Mueller and Anika Wahl},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  year={2001},
  volume={757 1},
  pages={49-57}
}
A sensitive, selective, robust and fast method to identify 32 diuretics and masking agents in urine is described. The analytical procedure is reduced to a single XAD extraction step for sample preparation, followed by reversed-phase liquid chromatography in combination with atmospheric pressure ionisation/tandem mass spectrometry. This technique is, after minor modifications, suitable for screening analyses and confirmation of identity as well as quantitation of diuretics. Considerations… CONTINUE READING

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