Screen-detected vs clinical breast cancer: the advantage in the relative risk of lymph node metastases decreases with increasing tumour size

@article{Bucchi2005ScreendetectedVC,
  title={Screen-detected vs clinical breast cancer: the advantage in the relative risk of lymph node metastases decreases with increasing tumour size},
  author={Lauro Bucchi and Alessandro Barchielli and Alessandra Ravaioli and Massimo R Federico and Vincenzo De Lisi and Stefano Ferretti and Eugenio Paci and Marcello Vettorazzi and Silvia Patriarca and Alfonso Frigerio and Eva Buiatti},
  journal={British Journal of Cancer},
  year={2005},
  volume={92},
  pages={156 - 161}
}
Screen-detected (SD) breast cancers are smaller and biologically more indolent than clinically presenting cancers. An often debated question is: if left undiagnosed during their preclinical phase, would they become more aggressive or would they only increase in size? This study considered a registry-based series (1988–1999) of 3329 unifocal, pT1a-pT3 breast cancer cases aged 50–70 years, of which 994 were SD cases and 2335 clinical cases. The rationale was that (1) the average risk of lymph… CONTINUE READING