Scratching the surface: signaling and routing dynamics of the CSF3 receptor.

@article{Palande2013ScratchingTS,
  title={Scratching the surface: signaling and routing dynamics of the CSF3 receptor.},
  author={Karishma K. Palande and Annemarie Meenhuis and Tanja Jevdjovic and Ivo P. Touw},
  journal={Frontiers in bioscience},
  year={2013},
  volume={18},
  pages={
          91-105
        }
}
Following activation by their cognate ligands, cytokine receptors undergo intracellular routing towards lysosomes where they are degraded. Cytokine receptor signaling does not terminate at the plasma membrane, but continues throughout the endocytotic pathway. The modes of internalization and intracellular trafficking of specific receptors, the level of recycling towards the plasma membrane, the type of protein modifications (phosphorylation, ubiquitination) and the enzymes involved in these… CONTINUE READING

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