Scratching the (lateral) surface of chromatin regulation by histone modifications

@article{Tropberger2013ScratchingT,
  title={Scratching the (lateral) surface of chromatin regulation by histone modifications},
  author={Philipp Tropberger and Robert Schneider},
  journal={Nature Structural \&Molecular Biology},
  year={2013},
  volume={20},
  pages={657-661}
}
Histones have two structurally and functionally distinct domains: globular domains forming the nucleosomal core around which DNA is wrapped and unstructured tails protruding from the nucleosomal core. Whereas post-translational modifications (PTMs) in histone tails are well studied, much less is currently known about histone-core PTMs. Many core PTMs map to residues located on the lateral surface of the histone octamer, close to the DNA, and they have the potential to alter intranucleosomal… 

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