Scratch induction in the rat by intradermal serotonin: a model for pruritus.

@article{Thomsen2001ScratchII,
  title={Scratch induction in the rat by intradermal serotonin: a model for pruritus.},
  author={Jens Schiersing Thomsen and Michael Bj\orn Petersen and Eva M Benfeldt and Svend B Jensen and J\orgen Vedelskov Serup},
  journal={Acta dermato-venereologica},
  year={2001},
  volume={81 4},
  pages={250-4}
}
Eight substances (histamine, compound 48/80, kallikrein, trypsin, papain, substance P, serotonin and platelet activating factor) were injected intradermally (volume 50 microl) into the rostral back (neck) of rats in order to establish an animal model for peripherally elicited pruritus. While serotonin induced excessive scratching at the site of injection, the other substances were weak or inactive. The dose-response relationship of serotonin was sigmoid, EC50=2.1 mg/ml (95% confidence interval… CONTINUE READING