Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells

@article{Taraboulos1990ScrapiePP,
  title={Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells},
  author={Albert Taraboulos and Dan Serban and Stanley B Prusiner},
  journal={The Journal of Cell Biology},
  year={1990},
  volume={110},
  pages={2117 - 2132}
}
The cellular prion protein (PrPC) is a sialoglycoprotein anchored to the external surface of cells by a glycosyl phosphatidylinositol moiety. During scrapie, an abnormal PrP isoform designated PrPSc accumulates, and much evidence argues that it is a major and necessary component of the infectious prion. Based on the resistance of native PrPSc to proteolysis and to digestion with phosphatidylinositol-specific phospholipase C as well as the enhancement of PrPSc immunoreactivity after denaturation… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 62 REFERENCES

Scrapie prion

  • N. Stahl, D. R. Borchelt, K. Hsiao, S. B. Prusiner
  • 1987
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

A novel sialoglycoprotein of the medial cisternal of the Golgi appara

  • G. Griffiths, K. Simons
  • 1989