Scrapie agent contains a hydrophobic protein.

  title={Scrapie agent contains a hydrophobic protein.},
  author={Stanley B Prusiner and Mark J McKinley and Darlene F Groth and Kimberley A Bowman and Nell I Mock and S P Cochran and Frank R. Masiarz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={78 11},
The scrapie agent causes a degenerative nervous system disorder of sheep and goats. Considerable evidence indicates that the scrapie agent contains a protein that is necessary for infectivity [Prusiner, S. B., Groth, D. F., Cochran, S. P., Masiarz, F. R., McKinley, M. P. & Martinez, H. M. (1980) Biochemistry 19, 4883-4891], but direct demonstration of a protein moiety has been hampered by lack of sufficiently purified preparations. Employing preparations of the scrapie agent enriched 100- to… CONTINUE READING