Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells

@inproceedings{Habartov2018ScoulerineAM,
  title={Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells},
  author={Kl{\'a}ra Habartov{\'a} and Radim Havelek and Martina Seifrtov{\'a} and Karel Kr{\'a}lovec and Lucie Cahl{\'i}kov{\'a} and Jakub Chlebek and Eva {\vC}erm{\'a}kov{\'a} and Nadě{\vz}da Maz{\'a}nkov{\'a} and Jana Marikova and Jiř{\'i} Kune{\vs} and Lenka Martinec Nov{\'a}kov{\'a} and Martina Řez{\'a}{\vc}ov{\'a}},
  booktitle={Scientific Reports},
  year={2018}
}
Scoulerine is an isoquinoline alkaloid, which indicated promising suppression of cancer cells growth. However, the mode of action (MOA) remained unclear. Cytotoxic and antiproliferative properties were determined in this study. Scoulerine reduces the mitochondrial dehydrogenases activity of the evaluated leukemic cells with IC50 values ranging from 2.7 to 6.5 µM. The xCELLigence system revealed that scoulerine exerted potent antiproliferative activity in lung, ovarian and breast carcinoma cell… CONTINUE READING
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