Scorpion Toxins Specific for Potassium (K+) Channels: A Historical Overview of Peptide Bioengineering

@inproceedings{Bergeron2012ScorpionTS,
  title={Scorpion Toxins Specific for Potassium (K+) Channels: A Historical Overview of Peptide Bioengineering},
  author={Zachary L. Bergeron and J Bingham},
  booktitle={Toxins},
  year={2012}
}
Scorpion toxins have been central to the investigation and understanding of the physiological role of potassium (K⁺) channels and their expansive function in membrane biophysics. As highly specific probes, toxins have revealed a great deal about channel structure and the correlation between mutations, altered regulation and a number of human pathologies. Radio- and fluorescently-labeled toxin isoforms have contributed to localization studies of channel subtypes in expressing cells, and have… CONTINUE READING

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Peptide backbone cyclization has been utilized to enhance therapeutic efficiency by augmenting serum stability and toxin half - life in vivo as a number of K⁺-channel isoforms have been identified with essential roles in disease states ranging from HIV , T - cell mediated autoimmune disease and hypertension to various cardiac arrhythmias and Malaria .
Peptide backbone cyclization has been utilized to enhance therapeutic efficiency by augmenting serum stability and toxin half - life in vivo as a number of K⁺-channel isoforms have been identified with essential roles in disease states ranging from HIV , T - cell mediated autoimmune disease and hypertension to various cardiac arrhythmias and Malaria .
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