Scorpion β-toxin interference with NaV channel voltage sensor gives rise to excitatory and depressant modes

@inproceedings{Leipold2012ScorpionI,
  title={Scorpion β-toxin interference with NaV channel voltage sensor gives rise to excitatory and depressant modes},
  author={Enrico Leipold and Adolfo Borges and Stefan H. Heinemann},
  booktitle={The Journal of general physiology},
  year={2012}
}
Scorpion β toxins, peptides of ∼70 residues, specifically target voltage-gated sodium (Na(V)) channels to cause use-dependent subthreshold channel openings via a voltage-sensor trapping mechanism. This excitatory action is often overlaid by a not yet understood depressant mode in which Na(V) channel activity is inhibited. Here, we analyzed these two modes of gating modification by β-toxin Tz1 from Tityus zulianus on heterologously expressed Na(V)1.4 and Na(V)1.5 channels using the whole cell… CONTINUE READING
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Tools for studying peptide toxin modulation of voltage - gated sodium channels

  • S. H. Heinemann, H. Terlau, W. Stühmer, K. Imoto, S. Numa
  • Toxins and Ion Transfers , SFET Editions
  • 2011

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