Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts.

@article{Mengel2009ScoringTI,
  title={Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts.},
  author={Michael 4 Mengel and J. O. Reeve and Sakarn Bunnag and Gunilla Einecke and Gian S. Jhangri and Banu Sis and Konrad S. Famulski and L Guembes-Hidalgo and Philip F. Halloran},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2009},
  volume={9 8},
  pages={1859-67}
}
Emerging molecular analysis can be used as an objective and independent assessment of histopathological scoring systems. We compared the existing Banff i-score to the total inflammation (total i-) score for assessing the molecular phenotype in 129 renal allograft biopsies for cause. The total i-score showed stronger correlations with microarray-based gene sets representing major biological processes during allograft rejection. Receiver operating characteristic curves showed that total-i was… CONTINUE READING