Scopolamine effects on memory, language, visuospatial praxis and psychomotor speed

@article{Flicker2005ScopolamineEO,
  title={Scopolamine effects on memory, language, visuospatial praxis and psychomotor speed},
  author={Charles Flicker and Michael J. Serby and Steven H. Ferris},
  journal={Psychopharmacology},
  year={2005},
  volume={100},
  pages={243-250}
}
Scopolamine hydrobromide was administered by subcutaneous injection to 30 young subjects in a dose of 0.22 mg/70 kg, 0.43 mg/70 kg, or 0.65 mg/70 kg. Treatment effects were compared to placebo on an extensive cognitive assessment battery. Almost all tests in the battery had been previously administered to Alzheimer's disease patients and nondemented elderly subjects. Scopolamine produced deficits on tests of verbal recall, visuospatial recall, visual recognition memory, visuospatial praxis… 
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Hypersensitivity to scopolamine in the elderly
TLDR
The results suggest that scopolamine's cognitive effects are quantitatively more pronounced in elderly subjects than young subjects, but that they are qualitatively similar and do not constitute a valid model for the cognitive dysfunction associated with Alzheimer's disease.
Age-related decline in central cholinergic function demonstrated with scopolamine
TLDR
There was a significant overall correlation between age and scopolamine-impaired performances on psychomotor speed, short-term recall, visual tracking speed, visuo-motor coordination, and sequencing ability, and the results provide further evidence that cholinergically mediated cognitive functions show an increased sensitivity to scopolamines with age.
Effects of Scopolamine on Matching to Sample Paradigm and Related Tests in Human Subjects
TLDR
The scopolamine-induced effects seem to be more relevant to Alzheimer’s disease in an advanced phase than to normal aging, and it is demonstrated that scopolamines has a greater effect on memory than on attention.
Specific impairments in visuospatial working and short-term memory following low-dose scopolamine challenge in healthy older adults
Effects of acute doses of oxiracetam in the scopolamine model of human amnesia
TLDR
The efficacy of an acute dose of oxiracetam in reducing scopolamine-induced cognitive impairment supports the potential usefulness of this pharmacological model of amnesia for studying the effects of cognition enhancers in humans.
Scopolamine impairs auditory delayed matching-to-sample performance in monkeys
Effect of cholinergic neurotransmission modulation on visual spatial paired associate learning in healthy human adults
TLDR
Support is provided for the use of a visual–spatial PAL test as a pharmacodynamic cognitive marker of central nervous system (CNS)-mediating compounds in humans following acute scopolamine challenge.
Cognitive performance and cholinergic transmission: influence of muscarinic and nicotinic receptor blockade
TLDR
Results show that scopolamine significantly impaired the free recall and recognition performance in the verbal learning test, and antagonism of muscarinic receptors resulted in specific cognitive impairments, predominantly memory performance.
Serotonergic modulation of anticholinergic effects on cognition and behavior in elderly humans
TLDR
The changes associated with the combination of scopolamine and m-CPP do not appear to be secondary to simple pharmacokinetic alterations and suggest a complex interaction between the cholinergic and serotonergic systems centrally.
RU 41 656 does not reverse the scopolamine-induced cognitive deficit in healthy volunteers
TLDR
Scopolamine caused anterograde amnesia and sedative effects as which were not counteracted by RU 41 656, and the effects of the compounds were evaluated by objective tests and subjective measurements.
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