Scopolamine deficits in negative patterning discrimination: evidence for a role of the central cholinergic system in retention but not acquisition of non-spatial configural association learning

@article{Moran1992ScopolamineDI,
  title={Scopolamine deficits in negative patterning discrimination: evidence for a role of the central cholinergic system in retention but not acquisition of non-spatial configural association learning},
  author={P. M. Moran},
  journal={Behavioural Brain Research},
  year={1992},
  volume={48},
  pages={187-197}
}
The effects of scopolamine (0.1 mg/kg s.c. and 0.6 mg/kg s.c.) were assessed on the acquisition and retention of a negative patterning discrimination task in rats. At 0.1 mg/kg scopolamine did not affect either acquisition or retention of the task. At 0.6 mg/kg scopolamine did not affect acquisition but did impair retention of the task. This impairment is likely to be centrally mediated as N-methyl scopolamine (0.6 mg/kg s.c.) did not affect retention. Lack of effect of scopolamine on… CONTINUE READING

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