Scopolamine as an Antidepressant: A Systematic Review

@article{Jaffe2013ScopolamineAA,
  title={Scopolamine as an Antidepressant: A Systematic Review},
  author={Robert J. Jaffe and Vladan Novakovic and Eric D. Peselow},
  journal={Clinical Neuropharmacology},
  year={2013},
  volume={36},
  pages={24–26}
}
ObjectivesThe cholinergic-adrenergic hypothesis of mania and depression states that depression is characterized by an increase in central cholinergic activity relative to noradrenergic tone. Scopolamine is a centrally acting competitive inhibitor of the muscarinic cholinergic receptor site. This review seeks to find all available data investigating scopolamine as an antidepressant. MethodsA systematic review of all the published and unpublished or ongoing literature was conducted via Ovid… 
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Demonstrating the Role of Anticholinergic Activity in a Mood Disorder
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M1 and M2 Muscarinic Receptor Subtypes Regulate Antidepressant-Like Effects of the Rapidly Acting Antidepressant Scopolamine
TLDR
Muscarinic M1 and M2 receptors are established as sufficient to generate behavioral effects consistent with an antidepressant phenotype and therefore as potential targets in the antidepressant effects of scopolamine.
A Key Role for Prefrontocortical Small Conductance Calcium-Activated Potassium Channels in Stress Adaptation and Rapid Antidepressant Response.
TLDR
Early behavioral and mPFC activational effects of scopolamine did not appear to depend on prefrontocortical brain-derived neurotrophic factor and serotonin-1A activity, classically linked to SSRIs, and suggest a novel mechanism associated with antidepressant response onset through SKC-mediated regulation of activity-dependent plasticity.
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The present results suggest the concoction of scopolamine with venlafaxine for enhanced synergistic antidepressive effects with the reduction of dose.
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