Scopolamine as an Antidepressant: A Systematic Review

@article{Jaffe2013ScopolamineAA,
  title={Scopolamine as an Antidepressant: A Systematic Review},
  author={Robert J. Jaffe and V. Novakovic and E. Peselow},
  journal={Clinical Neuropharmacology},
  year={2013},
  volume={36},
  pages={24–26}
}
  • Robert J. Jaffe, V. Novakovic, E. Peselow
  • Published 2013
  • Medicine
  • Clinical Neuropharmacology
  • ObjectivesThe cholinergic-adrenergic hypothesis of mania and depression states that depression is characterized by an increase in central cholinergic activity relative to noradrenergic tone. Scopolamine is a centrally acting competitive inhibitor of the muscarinic cholinergic receptor site. This review seeks to find all available data investigating scopolamine as an antidepressant. MethodsA systematic review of all the published and unpublished or ongoing literature was conducted via Ovid… CONTINUE READING
    35 Citations
    Rapid-Acting Antidepressants.
    • 19
    Demonstrating the Role of Anticholinergic Activity in a Mood Disorder
    • 3
    M1 and M2 Muscarinic Receptor Subtypes Regulate Antidepressant-Like Effects of the Rapidly Acting Antidepressant Scopolamine
    • 74
    • PDF
    Anticholinergic Activity and Schizophrenia
    • 7

    References

    SHOWING 1-10 OF 24 REFERENCES
    Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial.
    • 297
    • PDF
    Scopolamine Produces Larger Antidepressant and Antianxiety Effects in Women Than in Men
    • 83
    • PDF
    Replication of Scopolamine's Antidepressant Efficacy in Major Depressive Disorder: A Randomized, Placebo-Controlled Clinical Trial
    • 189
    • PDF
    The antidepressant effects of anticholinergic drugs.
    • R. Howland
    • Medicine
    • Journal of psychosocial nursing and mental health services
    • 2009
    • 23
    The effects of acute scopolamine in geriatric depression.
    • 53
    Serendipity Strikes Again: Scopolamine as an Antidepressant Agent in Bipolar Depressed Patients
    • D. Janowsky
    • Psychology, Medicine
    • Current psychiatry reports
    • 2011
    • 17
    Baseline mood-state measures as predictors of antidepressant response to scopolamine
    • 29
    THE EFFECTS OF DIISOPROPYLFLUOROPHOSPHONATE IN SCHIZOPHRENIA AND MANIC DEPRESSIVE PSYCHOSIS
    • 179
    • PDF