Scopolamine as an Antidepressant: A Systematic Review

@article{Jaffe2013ScopolamineAA,
  title={Scopolamine as an Antidepressant: A Systematic Review},
  author={Robert J. Jaffe and V. Novakovic and E. Peselow},
  journal={Clinical Neuropharmacology},
  year={2013},
  volume={36},
  pages={24–26}
}
  • Robert J. Jaffe, V. Novakovic, E. Peselow
  • Published 2013
  • Medicine
  • Clinical Neuropharmacology
    • ObjectivesThe cholinergic-adrenergic hypothesis of mania and depression states that depression is characterized by an increase in central cholinergic activity relative to noradrenergic tone. Scopolamine is a centrally acting competitive inhibitor of the muscarinic cholinergic receptor site. This review seeks to find all available data investigating scopolamine as an antidepressant. MethodsA systematic review of all the published and unpublished or ongoing literature was conducted via Ovid… CONTINUE READING
    View on Wolters Kluwer
    ncbi.nlm.nih.gov
    35 Citations
    Background Citations
    8
    Results Citations
    2
    35 Citations
    Citation Type

    Citation Type

    Modulation of muscarinic system with serotonin-norepinephrine reuptake inhibitor antidepressant attenuates depression in mice
    • 8
    The potential antidepressant action and adverse effects profile of scopolamine co-administered with the mGlu7 receptor allosteric agonist AMN082 in mice
    • 6
    Evaluating the effect of donepezil on depression and obsessive–compulsion disorder in mice models and proposing the mechanism involved
    Rapid-Acting Antidepressants.
    • 19
    Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs.
    • 132
    • PDF
    Mood Therapeutics: Novel Pharmacological Approaches for Treating Depression
    • 15
    Demonstrating the Role of Anticholinergic Activity in a Mood Disorder
    • 3
    M1 and M2 Muscarinic Receptor Subtypes Regulate Antidepressant-Like Effects of the Rapidly Acting Antidepressant Scopolamine
    • 74
    • PDF
    A Key Role for Prefrontocortical Small Conductance Calcium-Activated Potassium Channels in Stress Adaptation and Rapid Antidepressant Response.
    • 3
    • PDF
    Anticholinergic Activity and Schizophrenia
    • 7

    References

    SHOWING 1-10 OF 24 REFERENCES
    Modulation of muscarinic system with serotonin-norepinephrine reuptake inhibitor antidepressant attenuates depression in mice
    • 8
    Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial.
    • 297
    • PDF
    Scopolamine Produces Larger Antidepressant and Antianxiety Effects in Women Than in Men
    • 83
    • PDF
    Replication of Scopolamine's Antidepressant Efficacy in Major Depressive Disorder: A Randomized, Placebo-Controlled Clinical Trial
    • 189
    • PDF
    The antidepressant effects of anticholinergic drugs.
    • R. Howland
    • Medicine
    • Journal of psychosocial nursing and mental health services
    • 2009
    • 23
    The effects of acute scopolamine in geriatric depression.
    • 53
    Serendipity Strikes Again: Scopolamine as an Antidepressant Agent in Bipolar Depressed Patients
    • D. Janowsky
    • Psychology, Medicine
    • Current psychiatry reports
    • 2011
    • 17
    The effects of scopolamine on sleep and mood in depressed patients with a history of alcoholism and a normal comparison group
    • 54
    Baseline mood-state measures as predictors of antidepressant response to scopolamine
    • 29
    THE EFFECTS OF DIISOPROPYLFLUOROPHOSPHONATE IN SCHIZOPHRENIA AND MANIC DEPRESSIVE PSYCHOSIS
    • 179
    • PDF