Scope and mechanism of interstrand cross-link formation by the C4'-oxidized abasic site.

@article{Sczepanski2009ScopeAM,
  title={Scope and mechanism of interstrand cross-link formation by the C4'-oxidized abasic site.},
  author={Jonathan T Sczepanski and Aaron C. Jacobs and A. P. Nandi Majumdar and Marc M Greenberg},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 31},
  pages={11132-9}
}
The C4'-oxidized abasic site (C4-AP) is a commonly formed DNA lesion, which generates two types of interstrand cross-links (ICLs). The kinetically favored cross-link consists of two full length strands and forms reversibly and exclusively with dA. Cross-link formation is attributed to condensation of C4-AP with the N6-amino group of dA. Formation of the thermodynamic ICL involves cleavage of the strand containing C4-AP on the 3'-side of the lesion. The ratios and yields of the ICLs are highly… CONTINUE READING

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