Scope and Limitations of 3‐Iodo‐Kdo Fluoride‐Based Glycosylation Chemistry using N‐Acetyl Glucosamine Acceptors†

Abstract

The ketosidic linkage of 3-deoxy-d-manno-octulosonic acid (Kdo) to lipid A constitutes a general structural feature of the bacterial lipopolysaccharide core. Glycosylation reactions of Kdo donors, however, are challenging due to the absence of a directing group at C-3 and elimination reactions resulting in low yields and anomeric selectivities of the… (More)
DOI: 10.1002/open.201500126

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