Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma Plus LPS.

@article{Jang2005ScoparoneFA,
  title={Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma Plus LPS.},
  author={Seon Il Jang and Young-Jun Kim and Woojin Lee and Kyung Chell Kwak and Seung Hwa Baek and Gyu Beum Kwak and Y Yun and Tae-Oh Kwon and Hun Taeg Chung and Kyu-yun Chai},
  journal={Archives of pharmacal research},
  year={2005},
  volume={28 2},
  pages={203-8}
}
Scoparone is a major component of the shoot of Artemisia capillaris (Compositae), which has been used for the treatment of hepatitis and biliary tract infection in oriental countries. In the present study we observed that, scorparone exhibited no cytotoxic effect in unstimulated macrophages, but reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) upon stimulation by IFN-gamma/LPS or LPS. The inhibitory effects were found to be in conjuction with the suppression of inducible… CONTINUE READING

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