Scn2a-Null Heterozygosity Improves Survival and Modifies Neurocardiac Interaction in the Kcna1-Null Mouse Model of SUDEP

@article{Mishra2016Scn2aNullHI,
  title={Scn2a-Null Heterozygosity Improves Survival and Modifies Neurocardiac Interaction in the Kcna1-Null Mouse Model of SUDEP},
  author={Vikas A. Mishra and Nicky Gautier and Bharat Karumuri and Rui Liu and Ioannis K. Vlachos and Leonidas D. Iasemidis and Edward Glasscock},
  journal={2016 32nd Southern Biomedical Engineering Conference (SBEC)},
  year={2016},
  pages={135-135}
}
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, but its genetic etiology is largely unknown and likely complex involving multiple genes. The Kcna1 gene encodes Kv1.1 potassium channels that act to dampen neuronal excitability whereas the Scn2a gene encodes Nav1.2 sodium channels important for action potential conduction. We tested the hypothesis that subclinical Scn2a heterozygosity reduces SUDEP incidence in Kcna1-null mice of SUDEP, by… Expand