Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients.

@article{Cejka2012SclerostinSL,
  title={Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients.},
  author={Daniel Cejka and Agnes Jaeger-Lansky and Heidi Kieweg and Michael Weber and Christian Bieglmayer and Dominik Georg Haider and Danielle A Diarra and Janina Patsch and Franz Kainberger and Barbara Bohle and Martin Haas},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2012},
  volume={27 1},
  pages={226-30}
}
BACKGROUND Sclerostin is a soluble inhibitor of osteoblast function. Sclerostin is downregulated by the parathyroid hormone (PTH). Here, it was investigated whether sclerostin levels are influenced by intact (i) PTH and whether sclerostin is associated with bone turnover, microarchitecture and mass in dialysis patients. METHODS Seventy-six haemodialysis patients and 45 healthy controls were included in this cross-sectional study. Sclerostin, Dickkopf-1 (DKK-1), intact parathyroid hormone… CONTINUE READING

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