Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation.

@article{Sutherland2004SclerostinPT,
  title={Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation.},
  author={May S. Kung Sutherland and James C. Geoghegan and Changpu Yu and Eileen Turcott and John E Skonier and David G. Winkler and John A Latham},
  journal={Bone},
  year={2004},
  volume={35 4},
  pages={828-35}
}
A null mutation in the SOST gene is associated with sclerosteosis, an inherited disorder characterized by a high bone mass phenotype. The protein product of the SOST gene, sclerostin, is a bone morphogenetic protein (BMP) antagonist that decreases osteoblast activity and reduces the differentiation of osteoprogenitors. We sought to delineate the mechanism by which sclerostin modulated osteoblastic function by examining the effects of the protein on differentiating cultures of human mesenchymal… CONTINUE READING