Sclerostin induced tumor growth, bone metastasis and osteolysis in breast cancer

@inproceedings{Zhu2017SclerostinIT,
  title={Sclerostin induced tumor growth, bone metastasis and osteolysis in breast cancer},
  author={Menghai Zhu and ChangZhen Liu and Shifei Li and Shudong Zhang and Qi Yao and Qingkun Song},
  booktitle={Scientific Reports},
  year={2017}
}
Breast cancer is the second leading cause of cancer-related deaths among women worldwide. Many patients suffer from bone metastasis. Sclerostin, a key regulator of normal bone remodeling, is critically involved in osteolytic bone diseases. However, its role in breast cancer bone metastasis remains unknown. Here, we found that sclerostin was overexpressed in breast cancer tumor tissues and cell lines. Inhibition of sclerostin by antibody (Scl-Ab) significantly reduced migration and invasion of… CONTINUE READING
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