Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model.

  title={Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model.},
  author={Cristal S. Yee and Liqin Xie and Sarah J. Hatsell and Nicholas R. Hum and Deepa K. Murugesh and Aris N. Economides and Gabriela G. Loots and Nicole M.B. Collette},
Type 1 diabetes mellitus (T1DM) patients have osteopenia and impaired fracture healing due to decreased osteoblast activity. Further, no adequate treatments are currently available that can restore impaired healing in T1DM; hence a significant need exists to investigate new therapeutics for treatment of orthopedic complications. Sclerostin (SOST), a WNT antagonist, negatively regulates bone formation, and SostAb is a potent bone anabolic agent. To determine whether SOST antibody (SostAb… CONTINUE READING
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