Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading.

@article{Spatz2013SclerostinAI,
  title={Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading.},
  author={Jordan M. Spatz and Rachel Ellman and A. M. Cloutier and Leeann Louis and Miranda van Vliet and Larry J. Suva and Denise Dwyer and Marina Stolina and Hua Zhu Ledyard Ke and Mary L Bouxsein},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2013},
  volume={28 4},
  pages={
          865-74
        }
}
Sclerostin, a product of the SOST gene produced mainly by osteocytes, is a potent negative regulator of bone formation that appears to be responsive to mechanical loading, with SOST expression increasing following mechanical unloading. We tested the ability of a murine sclerostin antibody (SclAbII) to prevent bone loss in adult mice subjected to hindlimb unloading (HLU) via tail suspension for 21 days. Mice (n = 11-17/group) were assigned to control (CON, normal weight bearing) or HLU and… CONTINUE READING
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