Sclerosing Rhabdomyosarcoma in Adults: Report of Four Cases of a Hyalinizing, Matrix-Rich Variant of Rhabdomyosarcoma That May Be Confused With Osteosarcoma, Chondrosarcoma, or Angiosarcoma

@article{Folpe2002SclerosingRI,
  title={Sclerosing Rhabdomyosarcoma in Adults: Report of Four Cases of a Hyalinizing, Matrix-Rich Variant of Rhabdomyosarcoma That May Be Confused With Osteosarcoma, Chondrosarcoma, or Angiosarcoma},
  author={Andrew L. Folpe and Jesse K. McKenney and Julia A Bridge and Sharon Whelan Weiss},
  journal={The American Journal of Surgical Pathology},
  year={2002},
  volume={26},
  pages={1175-1183}
}
Rhabdomyosarcomas (RMSs) are classified into embryonal (ERMS), alveolar (ARMS), and pleomorphic (PRMS) subtypes. ERMS, including botryoid variants, typically occurs in young children, ARMS typically occurs in older children and young adults, and PRMS occurs in older adults. Although ARMSs show thin fibrous bands separating nests of cells, abundant extracellular matrix production is rare in RMS. In the course of reviewing hyalinizing sarcomas we discovered a distinctive RMS in adults that… 

Sclerosing Rhabdomyosarcoma: Report of a Case Arising in the Head and Neck of an Adult and Review of the Literature

Controversy is discussed regarding how sclerosing rhabdomyosarcoma might best fit into existing rhabDomyosARcoma classification schemes, based upon current clinicopathologic and molecular genetic evidence.

[Spindle cell rhabdomyosarcoma in adults: a new entity in the spectrum of malignant mesenchymal tumors of soft tissues].

Spindle cell and sclerosing RMS in adults arise predominantly in the head and neck region and on the extremities, and are composed of atypical spindled cells and scattered rhabdomyoblasts.

Sclerosing Rhabdomyosarcomas in Children and Adolescents: A Clinicopathologic Review of 13 Cases From the Intergroup Rhabdomyosarcoma Study Group and Children’s Oncology Group

  • Melissa C. ChilesD. Parham W. Meyer
  • Medicine
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2005
Sclerosing RMS may arise in children, have mixed ERMS-ARMS histology, originate from the head and neck, and lack strong myogenin staining.

Sclerosing Rhabdomyosarcoma: Presentation of a Rare Sarcoma Mimicking Myoepithelial Carcinoma of the Parotid Gland and Review of the Literature

A case of SRMS mimicking a myoepithelial carcinoma of the parotid gland is reported, highlighting the potential for misdiagnosis as a primary salivary gland epithelial malignancy.

Sclerosing Rhabdomyosarcoma in Childhood: Case Report and Review of the Literature

  • B. VadgamaN. SebireM. MaloneA. Ramsay
  • Medicine
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2004
The histology, immunohistochemistry, and molecular genetics matched those reported in the seven adult cases of sclerosing rhabdomyosarcoma, and this is the first case report, to the authors' knowledge, of this rare tumor arising in the pediatric age group.

Sclerosing rhabdomyosarcoma: a clinicopathologic and immunohistochemical study of five cases.

5 cases of sclerosing rhabdomyosarcoma are described, which are reported to represent a special variant of rhab DomyosARcoma and is possibly related to embryonal rhabDomyosArcoma, the most common malignant soft tissue tumor of childhood and adolescence.

Adult-type Rhabdomyosarcoma: Analysis of 57 Cases With Clinicopathologic Description, Identification of 3 Morphologic Patterns and Prognosis

Adult-type rhabdomyosarcoma is a rare sarcoma occurring mainly in the extremities and trunk wall with 2 main histologic patterns, spindle cell, and pleomorphic patterns, which represent the end of the spectrum of a single entity.

Sclerosing pseudovascular rhabdomyosarcoma—immunohistochemical, ultrastructural, and genetic findings indicating a distinct subtype of rhabdomyosarcoma

These findings represent a relatively circumscribed genetic defect pattern in sclerosing (pseudovascular) rhabdomyosarcoma that is somewhat different from patterns described in most other rhabDomyosARcoma subtypes.

Sclerosing rhabdomyosarcoma of the parotid gland in an adult.

Spindle cell/sclerosing rhabdomyosarcoma: case series from a single institution emphasizing morphology, immunohistochemistry and follow-up.

It is demonstrated there do present some clincopathologic relations between spindle cells rhabdomyosarcoma and sclerosing rhabDomyosARcoma, but the latter seems to have a better prognosis.
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