Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells

@inproceedings{Gilbane2013SclerodermaPA,
  title={Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells},
  author={Adrian J Gilbane and Christopher P. Denton and Alan Holmes},
  booktitle={Arthritis research & therapy},
  year={2013}
}
Scleroderma (systemic sclerosis; SSc) is characterised by fibrosis of the skin and internal organs in the context of autoimmunity and vascular perturbation. Overproduction of extracellular matrix components and loss of specialised epithelial structures are analogous to the process of scar formation after tissue injury. Fibroblasts are the resident cells of connective tissue that become activated at sites of damage and are likely to be important effector cells in SSc. Differentiation into… CONTINUE READING
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