Scleroderma keratinocytes promote fibroblast activation independent of transforming growth factor beta.

Abstract

Objectives SSc is a devastating disease that results in fibrosis of the skin and other organs. Fibroblasts are a key driver of the fibrotic process through deposition of extracellular matrix. The mechanisms by which fibroblasts are induced to become pro-fibrotic remain unclear. Thus, we examined the ability of SSc keratinocytes to promote fibroblast… (More)
DOI: 10.1093/rheumatology/kex280

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