Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor alpha-receptor.

@article{Ohba1994SclerodermaBL,
  title={Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor alpha-receptor.},
  author={Tetsuro Ohba and John K. McDonald and Richard M. Silver and Charlie Strange and Elizabeth C Leroy and A Ludwicka},
  journal={American journal of respiratory cell and molecular biology},
  year={1994},
  volume={10 4},
  pages={405-12}
}
In addition to its procoagulant properties, the serine protease thrombin increases endothelial permeability, stimulates granulocyte adherence, and serves as a fibroblast mitogen. We demonstrate that thrombin is mitogenic for human lung fibroblasts in vitro. The mitogenic effect of thrombin is associated with an increase in the expression of the ligand PDGF-AA and up-regulation of PDGF alpha-receptor. Since scleroderma (systemic sclerosis; SSc) is characterized by widespread microvascular injury… CONTINUE READING