Scleroderma: from pathophysiology to novel therapeutic approaches.

@article{Hunzelmann2010SclerodermaFP,
  title={Scleroderma: from pathophysiology to novel therapeutic approaches.},
  author={Nicolas Hunzelmann and Thomas Krieg},
  journal={Experimental dermatology},
  year={2010},
  volume={19 5},
  pages={
          393-400
        }
}
Systemic scleroderma may serve as a paradigm for orphan diseases where the rarity, different subsets and fluctuating disease activity constitute major obstacles of research into mechanisms and therapeutic development. Recently, significant advances in the detailed understanding of the functioning of growth factors, their receptors and of the physiology of the connective tissue have been achieved. In particular, an improved concept was developed for the pathophysiology of scleroderma… CONTINUE READING
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