Scleral permeability of a small, single-stranded oligonucleotide.

  title={Scleral permeability of a small, single-stranded oligonucleotide.},
  author={Robert Shuler and Phyllis K Dioguardi and Charles Henjy and John M. Nickerson and Lars P. J. Cruysberg and Henry F. Francis Edelhauser},
  journal={Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics},
  volume={20 2},
Developing more effective ocular drug delivery systems is essential to improving the treatment of posterior segment eye disease. The large target area provided by the sclera and potentially less vision threatening complications are advantages of transscleral administration compared to more traditional modalities of drug delivery to the posterior segment. We aimed to determine the permeability coefficient for the in vitro diffusion of a small, single-stranded, oligonucleotide across human sclera… CONTINUE READING