Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice

@article{Dimas2006SclareolIA,
  title={Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice},
  author={Konstantinos Dimas and Sophia Hatziantoniou and Sophia Tseleni and Humaira Afreen Khan and Aristidis Georgopoulos and Konstantinos Alevizopoulos and James H. Wyche and Panayotis Pantazis and Costas Demetzos},
  journal={Apoptosis},
  year={2006},
  volume={12},
  pages={685-694}
}
Labd-14-ene-8, 13-diol (sclareol) is a labdane-type diterpene, which has demonstrated significant cytotoxic activity against human leukemic cell lines, but its effect on solid tumor-derived cells is uknown. Here, we demonstrate that addition of sclareol to cultures of human colon cancer HCT116 cells results in inhibition of DNA synthesis, arrest of cells at the G1 phase of the cell cycle, activation of caspases-8, -9, PARP degradation, and DNA fragmentation, events characteristic of induction… CONTINUE READING

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