Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells.

@article{Ren2010SclIA,
  title={Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells.},
  author={Xi Ren and Gustavo A. Gomez and Bo Zhang and Shuo Lin},
  journal={Blood},
  year={2010},
  volume={115 26},
  pages={
          5338-46
        }
}
Recent lineage studies suggest that hematopoietic stem cells (HSCs) may be derived from endothelial cells. However, the genetic hierarchy governing the emergence of HSCs remains elusive. We report here that zebrafish ets1-related protein (etsrp), which is essential for vascular endothelial development, also plays a critical role in the initiation of definitive hematopoiesis by controlling the expression of 2 stem cell leukemia (scl) isoforms (scl-alpha and scl-beta) in angioblasts. In etsrp… CONTINUE READING