Scintillation proximity assays in high-throughput screening.

  title={Scintillation proximity assays in high-throughput screening.},
  author={J Fraser Glickman and Andres Schmid and Sandrine Ferrand},
  journal={Assay and drug development technologies},
  volume={6 3},
Scintillation proximity assays (SPAs) have become a powerful tool for high-throughput screening (HTS) because they can measure the activity and binding of very diverse classes of drug targets. By applying the basic principles of ligand-receptor binding and enzyme kinetics, it is possible to build a large variety of miniaturized, high-throughput assays and screen millions of compounds. SPAs are enabled by the diversity of radiolabeled molecules and affinity tags that are commercially available… CONTINUE READING

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