Scintigraphy with 111In-labeled autologous platelets in venous thromboembolism.

Abstract

Scintigraphy with 111in-labeled autologous platelets was performed in 20 patients with suspected venous thrombosis and/or pulmonary embolism. The platelets accumulated in venous thrombi in 6 or 7 patients (86%) with positive findings on impedance plethysmography or contrast venography; all 6 were receiving intravenous heparin. In 11 patients with pulmonary embolism diagnosed by ventilation--perfusion imaging or pulmonary angiography, platelet scintigraphy showed embolic uptake only in the one patient not on full-dose heparin. These findings suggest that scintigraphy with 111In-platelets is a promising noninvasive technique for detection of deep venous thrombosis. Heparin does not appear to block localization of labeled platelets in venous thrombi, but may inhibit their adherence to pulmonary emboli.

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@article{Davis1980ScintigraphyW1, title={Scintigraphy with 111In-labeled autologous platelets in venous thromboembolism.}, author={Henry Hap Davis and Barry A. Siegel and Laurence A Sherman and William Andrew Heaton and Michael J. Welch}, journal={Radiology}, year={1980}, volume={136 1}, pages={203-7} }