Scintigraphic visualization of intrathecal liposome biodistribution.

Abstract

BACKGROUND Liposomes containing local anaesthetics have been administered intrathecally and in the epidural space. Poor attention has been given to the pharmacokinetics of liposomes as drug carriers. Therefore, we observed the biodistribution of liposomes after intrathecal injection in rats by scintigraphic imaging during 24 h. METHODS We administered… (More)

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