Scintigraphic study to investigate the effect of food on a HPMC modified release formulation of UK-294,315.

@article{Davis2009ScintigraphicST,
  title={Scintigraphic study to investigate the effect of food on a HPMC modified release formulation of UK-294,315.},
  author={John D Davis and John Burton and Alyson L. Connor and Robert Macrae and Ian R. Wilding},
  journal={Journal of pharmaceutical sciences},
  year={2009},
  volume={98 4},
  pages={1568-76}
}
The objective of the study was to use the combined approach of gamma scintigraphy and pharmacokinetics, in order to understand the mechanisms explaining the pharmacokinetic differences observed for a modified release (MR) formulation, when administered either in the fed or fasted state. Ten healthy subjects were recruited into a randomized three period single dose study, each subject receiving UK-294,315 40 mg IR (fasted), 100 mg MR (fasted) or 100 mg MR (after a high fat meal). C(max) values… CONTINUE READING
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