References
SHOWING 1-6 OF 6 REFERENCES
Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets
- BiologyScience
- 2012
Avian A/H5N1 influenza viruses can acquire the capacity for airborne transmission between mammals without recombination in an intermediate host and therefore constitute a risk for human pandemic influenza.
H5N1 Hybrid Viruses Bearing 2009/H1N1 Virus Genes Transmit in Guinea Pigs by Respiratory Droplet
- BiologyScience
- 2013
Transmission studies showed that the H1N1 virus genes encoding acidic polymerase and nonstructural protein made the H5N1irus transmissible by respiratory droplet between guinea pigs without killing them, suggesting that avian H5n1 subtype viruses do have the potential to acquire mammalian transmissibility by reassortment in current agricultural scenarios.
Experimental adaptation of an influenza H5 haemagglutinin (HA) confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
- BiologyNature
- 2012
Results indicate that H5 HA can convert to an HA that supports efficient viral transmission in mammals, and will help individuals conducting surveillance in regions with circulating H5N1 viruses to recognize key residues that predict the pandemic potential of isolate, which will inform the development, production and distribution of effective countermeasures.
Lack of transmission of H5N1 avian–human reassortant influenza viruses in a ferret model
- Biology, MedicineProceedings of the National Academy of Sciences
- 2006
It is suggested that H5N1 viruses may require further adaptation to acquire this essential pandemic trait, and the complexity of the genetic basis of influenza virus transmissibility is highlighted.
Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice.
- Biology, MedicineAntiviral research
- 2012
Increased Pathogenicity of a Reassortant 2009 Pandemic H1N1 Influenza Virus Containing an H5N1 Hemagglutinin
- BiologyJournal of Virology
- 2011
Reassortment between cocirculating human pH1N1 and avian H5N1 influenza strains will result in a virus with the potential for increased pathogenicity in mammals, suggesting that these viruses easily adapt to humans and become more virulent.