Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain

  title={Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain},
  author={Roger A. Barker and Inez de Beaufort},
  journal={Progress in Neurobiology},

Figures and Tables from this paper

Ethical Challenges of Stem-Cell Transplantation in Parkinson's Disease: Islamic Viewpoint

We read with great interest the article entitled “Ethical Criteria for Human Trials of Stem-Cell-Derived Dopaminergic Neurons in Parkinson’s Disease” by Hurst and colleagues (2015). Hurst and

Cell therapies for Parkinson's disease: how far have we come?

There is now much interest in how dopaminergic neurons derived from stem cell sources could be used to develop cell-based therapies suitable for clinical use, with clinical trials poised to enter the clinic in the next couple of years.

Are Stem Cell-Based Therapies for Parkinson’s Disease Ready for the Clinic in 2016?

The current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial is described and the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson’s disease is critically assessed.

Could Stem Cells Be Used to Treat or Model Alzheimer’s Disease?

The mechanisms that underlie the effects of stem cell transplantation and the considerable challenge in translating these findings toward clinical trials are examined and the potential clinical and disease-modeling applications of patient-derived iPSCs for AD are discussed.

Stem Cell-Based Therapies for Polyglutamine Diseases.

In this chapter the main advantages and disadvantages of the available sources of stem cells as well as their efficacy and potential to improve disease outcomes are discussed.

Recent advances in stem cells therapy: A focus on cancer, Parkinson’s and Alzheimer’s

Organoid and pluripotent stem cells in Parkinson’s disease modeling: an expert view on their value to drug discovery

The use of Parkinson’s disease patient-derived neurons and organoids provides the exciting opportunity to directly investigate pathogenic mechanisms and test drug compounds in human neurons.

An overview on ethical considerations in stem cell research in Iran and ethical recommendations: A review

  • T. Farajkhoda
  • Business
    International journal of reproductive biomedicine
  • 2017
There is a necessity for extending global networks of bioethics for strengthening communications within organizations at both the regional and international level, strengthening legislation systems, designing and establishing convenient collaborative educational courses at different levels.



Embryo Stem Cell Research: Ten Years of Controversy

The main issues that have bedeviled stem cell progress are assessed and the ethical fault lines that are likely to continue are identified and the field is poised for a period of rapid development.

Uncertain Translation, Uncertain Benefit and Uncertain Risk: Ethical Challenges Facing First‐In‐Human Trials of Induced Pluripotent Stem (IPS) Cells

It is concluded that iPS cell research should not replace, but proceed alongside embryonic and adult somatic stem cell research to promote cross-fertilisation of knowledge and better clinical outcomes.

Stem cell treatment in Amyotrophic Lateral Sclerosis

Stem cell therapy in amyotrophic lateral sclerosis: a methodological approach in humans

  • L. MazziniF. Fagioli E. Madon
  • Medicine, Biology
    Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
  • 2003
The results appear to demonstrate that the procedures of ex vivo expansion of autologous mesenchymal stem cells and of transplantation into the spinal cord of humans are safe and well tolerated by ALS patients.

Immunogenicity of induced pluripotent stem cells.

A new study shows the immunogenicity of induced pluripotent stem cells by the direct transplantation of undifferentiated cells into syngenic mice, indicating that cells differentiated from iPSCs can at least partially replace the biological functions of various organs.

Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: scientific and ethical considerations

Parkinson's disease and growth factors - are they the answer?

  • R. Barker
  • Biology, Psychology
    Parkinsonism & related disorders
  • 2009

Neural grafting in Parkinson's disease Problems and possibilities.