Purpose: The nephrotic syndrome is associated with protein loss from the kidneys, hypalbuminaemia, and hypercholestrinaemia. In patients with this syndrome resistant to therapy and life threatening protein loss, a percutaneous transfemoral kidney ablation can be performed as a last measure. Methods and Materials: In 3 patients, 1 with membrano-proliferative glomerulonephritis and 2 with amyloidosis, a bilateral renal artery embolization performed with Gianturco coils. Results: In all cases the percutaneous performed kidney ablation was able to successfully terminate proteinuria. Nevertheless, one patient died 14 days later because of septicaemia and sepsis, due to prolonged loss of gammaglobulin. The other 2 patients survived, though for permanent hemodialysis. Conclusion: In life-threatening desperate situations, catheter aided renal embolization is a quick and effective alternative to nephrectomy.